University of Oklahoma Health Sciences Center

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Author/s:

Jeimy, Samira, Zhu, Rongbo

Date Added:

October 8, 2023

Journal/Publication:

CMAJ

Publisher:

CMA

Publication Date:

October 3, 2023

Issue:

Volume:

195

URL:

Tick-borne red meat allergy (α-gal syndrome)

Type:

Meta-analyses, Reviews, and Guidelines

Format:

Article

DOI (1):

10.1503/cmaj.231067

PMID (1):

37788844

Keywords

tick-borne illness

Allergic reactions

red meat allery

MeSH

Tick Bites

Ticks

Allergic

RPR Commentary

A consice summary of the cause, diagnosis, and consequences of alpha-gal syndrome (red meat allergy secondary to tick bite). James W. Mold, MD, MPH

Abstract

Tick-borne red meat allergy occurs from sensitization to a carbohydrate, galactose-α-1,3-galactose (α-gal)

The lone star tick (Amblyomma americanum) is commonly found in the southern United States, but its prevalence in Canada is increasing.1 The tick’s saliva contains a high level of α-gal, a carbohydrate antigen also present in nonprimate mammalian cell membranes.2 Skin and bloodstream exposure to this antigen through a tick bite leads to sensitization to the carbohydrate and, subsequently, to red meat allergy.

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