University of Oklahoma Health Sciences Center

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Author/s:

Koyama, T., Nagata, N., Nishiura, K., Miura, N., Kawai, T., Yamamota, H.

Date Added:

October 22, 2022

Journal/Publication:

American Journal of Gastroenterology

Publisher:

Wolters Kluwer Health

Publication Date:

August 12, 2022

Issue:

Volume:

117

Pages:

1714-1717

URL:

Prune Juice Containing Sorbitol, Pectin, and Polyphenol Ameliorates Subjective Complaints and Hard Feces While Normalizing Stool in Chronic Constipation: A Randomized Placebo-Controlled Trial

Type:

Clinical Research Results

Format:

Article

DOI (1):

10.14309/ajg.0000000000001931

PMID (1):

35971232

Keywords

Pectins

Feces

Dietary Fiber

Double-Blind Method

randomized control trial

MeSH

Sorbitol*

Constipation / drug therapy

Diarrhea / drug therapy

Defecation

Polyphenols*

RPR Commentary

Prune juice inexpensively resolves chronic constipation without causing diarrhea or increasing gas. James W. Mold, MD, MPH

Abstract

Introduction: The aim of this study was to determine the effectiveness of prune juice on chronic constipation.

Methods: We conducted a double-blind, randomized, placebo-controlled trial in Japanese subjects with chronic constipation.

Results: Prune intake significantly decreased hard and lumpy stools while increasing normal stool and not increasing loose and watery stools. Prune intake also ameliorated subjective complaints of constipation and hard stools, without alteration of flatulence, diarrhea, loose stools, or urgent need for defecation. There were no adverse events or laboratory abnormalities of liver or renal function after prune intake.

Discussion: Prune juice exerted an effective and safe natural food therapy for chronic constipation.

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