University of Oklahoma Health Sciences Center

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Author/s:

Shi, Yu, Wu, Wen

Date Added:

October 8, 2023

Journal/Publication:

BMC Medicine

Publisher:

BMC

Publication Date:

September 29, 2023

Issue:

372

Volume:

URL:

Multimodal non-invasive non-pharmacological therapies for chronic pain: mechanisms and progress

Type:

Meta-analyses, Reviews, and Guidelines

Format:

Article

DOI (1):

10.1186/s12916-023-03076-2

PMID (1):

37775758

Keywords

chronic pain

MeSH

Clinical Protocols

chronic disease

Chronic Pain* / therapy

RPR Commentary

A lengthy review of nonpharmacologic treatments for chronic pain including proposed mechanisms and current evidence. James W. Mold, MD, MPH

Abstract

Chronic pain conditions impose significant burdens worldwide. Pharmacological treatments like opioids have limitations. Non-invasive non-pharmacological therapies (NINPT) encompass diverse interventions including physical, psychological, complementary and alternative approaches, and other innovative techniques that provide analgesic options for chronic pain without medications.
Main body

This review elucidates the mechanisms of major NINPT modalities and synthesizes evidence for their clinical potential across chronic pain populations. NINPT leverages peripheral, spinal, and supraspinal mechanisms to restore normal pain processing and limit central sensitization. However, heterogeneity in treatment protocols and individual responses warrants optimization through precision medicine approaches.
Conclusion

Future adoption of NINPT requires addressing limitations in standardization and accessibility as well as synergistic combination with emerging therapies. Overall, this review highlights the promise of NINPT as a valuable complementary option ready for integration into contemporary pain medicine paradigms to improve patient care and outcomes.

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