University of Oklahoma Health Sciences Center

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Author/s:

M. S., Wagner, J., Ahmed, A. Y., Morasco, B., Kansagara, D., Chou, R.

Date Added:

July 6, 2021

Type:

Meta-analyses, Reviews, and Guidelines

MeSH

cannabis

cannabinoids

chronic pain

Mitragyna

Research Report

Hallucinogens

Publications

Health Services Research

delivery of health care

medical marijuana

RPR Commentary

Plant-based analgesics appear to have relatively low efficacy and high rates of adverse effects.

Abstract

This is the third quarterly progress report for an ongoing living systematic review on
cannabis and other plant-based treatments for chronic pain. The first progress report was
published in January 2021 and the second in March 2021. The draft systematic review was
available for public comment from May 19 through June 15, 2021, on the Agency for Healthcare
Research and Quality (AHRQ) Effective Health Care website. The systematic review synthesizes
evidence on the benefits and harms of plant-based compounds (PBCs), such as cannabinoids and
kratom, used to treat chronic pain, addressing concerns about severe adverse effects, abuse,
misuse, dependence, and addiction.
The purpose of this progress report is to describe the cumulative literature identified thus far.
This report will be periodically updated with new studies as they are published and identified,
culminating in an annual systematic review that provides a synthesis of the accumulated
evidence.

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain - Quarterly Progress Report: May 2021

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RPR Commentary

Abstract