University of Oklahoma Health Sciences Center

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Author/s:

Kristen M. Marks, Andrew M. Davis

Date Added:

June 30, 2026

Journal/Publication:

JAMA

Publisher:

The American Medical Association

Publication Date:

June 30, 2026

Pages:

E1-E2

URL:

Antiviral Therapies for Adults with Mild to Moderate COVID-19 Infection

Type:

Meta-analyses, Reviews, and Guidelines

Format:

Article

DOI (1):

doi: 10.1001/jama.2026.6918

Keywords

COVID-19

Antiviral

MeSH

antiviral agents

COVID-19

RPR Commentary

RPR Commentary: 2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America (IDSA) on the Treatment and Management of COVID-19: Antiviral Treatment for Mild to Moderate COVID-19 in Adults. James W. Mold, MD, MPH

Abstract

With increasing population immunity through vaccination and prior infection, the risk of severe COVID-19, hospitalization, and death has substantially decreased in all age groups in the US since 2021.1 However, certain populations, especially those aged 65 years or older, remain at increased risk for progression to severe disease. This updated guideline provides a risk-stratified approach to antiviral therapies for patients with mild to moderate COVID-19 (defined as symptoms of respiratory infection with oxygen saturation >94% while breathing room air). Antiviral therapies are most effective when initiated within 5 to 7 days of COVID-19 symptom onset.

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