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Bisphosphonates for Postmenopausal Osteoporosis

Author/s: 
Ensrud, KE, Crandall, CJ

Bisphosphonates are the first-line pharmacologic treatment for postmenopausal osteoporosis and the most commonly prescribed medication for this condition.1 Bisphosphonates, classified as antiresorptive agents, have a very high affinity for bone mineral and bind to hydroxyapatite crystals on bony surfaces, where they inhibit osteoclast-mediated bone resorption.

Keywords 
post-menopausal osteoporosis bisphosphonates antiresorptive agents

Drug Threat Bulletin: DSUVIA (Sufentanil)

Author/s: 
Oklahoma Bureau of Narcotics and Dangerous Drugs

The US Food and Drug Administration (FDA) approved DSUVIA, the synthetic opioid sufentanil in tiny blue tablet form, on Nov. 2, 2018 for single doses ingested under the tongue. Sufentanil is chemically similar to fentanyl (the lethal narcotic showing up as fake oxycodone pills and as a cutting agent in heroin) but estimated to be five to 10 times stronger. The opioid has been administered in solution form via IV and epidural injection since 1984, and typically employed as an anesthesia during major surgery (high dose) and in low-dosages as part of pain-relieving regimen for general surgery. (ROCIC Drug Publication)

Keywords 
DSUVIA opioids opioid-use disorder sufentanil

Featured Review: Vertebroplasty for treating spinal fractures due to osteoporosis

Author/s: 
Buchbinder, Rachelle, Johnston, Renea V., Rischin, Kobi J., Jomik, Joanne, Jones, C. Allyson, Golmohammadi, Kamran, Kallmes, David F.

High quality evidence shows that vertebroplasty does not provide more clinically important benefits than placebo but may cause people harm.

Keywords 
vertebroplasty osteoporosis spine
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