Antibiotic-associated adverse drug reactions are often mild (eg, nausea or diarrhea) and typically occur 1 to 6 hours after drug exposure. IgE-mediated reactions cause urticaria, angioedema, bronchospasm, or, in severe cases, anaphylaxis. Cell-mediated delayed hypersensitivity can occur over...
Recent Resources
Clinical Approaches to the Prevention of Firearm-Related Injury
Firearm-related injuries are an urgent health crisis in the United States, with firearm-related deaths surpassing deaths from motor vehicle crashes in 2017.1 In contrast to other conditions for which clinicians have evidence-based solutions to reduce harm, the 25-year gap in federal research...
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Scabies, Bedbug, and Body Lice Infestations: A Review
Importance: Scabies, bedbug, and body lice infestations are caused by organisms that live on or in the skin, on clothing, or in the environment and commonly cause pruritus and rash. In 2021, approximately 622 million incident cases of scabies occurred globally. Data on bedbug infestations are...
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Conservative Treatments in the Management of Acute Painful Vertebral Compression Fractures: A Systematic Review and Network Meta-Analysis
Importance: Osteoporotic vertebral compression fractures (VCFs) frequently cause substantial pain and reduced mobility, posing a major health problem. Despite the critical need for effective pain management to restore functionality and improve patient outcomes, the value of various conservative...
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Protection against influenza hospitalizations from enhanced influenza vaccines among older adults: A systematic review and network meta-analysis
Background
Influenza vaccines are available to help protect persons aged ≥65 years, who experience thousands of influenza hospitalizations annually. Because some influenza vaccines may work better than others, we sought to assess benefit of high-dose (HD), adjuvanted (ADJ), and recombinant...
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Parkinson's Disease
The global burden of Parkinson’s disease is projected to increase in future decades as the number and proportion of older adults increases. This review addresses research advances since 1998, when the disorder was last reviewed in the Journal, and includes recently introduced concepts relevant...
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Renal Cell Carcinoma: A Review
Importance: Renal cell carcinoma (RCC) is a common malignancy, with an estimated 434 840 incident cases worldwide in 2022. In the US, it is the sixth most common cancer among males and ninth among females.
Observations: Clear cell RCC is the most common histologic subtype (75%-80% of...
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Topical anti-inflammatory treatments for eczema: network meta-analysis
Background: Eczema (atopic dermatitis) is the most burdensome skin condition worldwide and cannot currently be prevented or cured. Topical anti-inflammatory treatments are used to control eczema symptoms, but there is uncertainty about the relative effectiveness and safety of different topical...
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Buprenorphine for Opioid Use Disorder-An Essential Medical Treatment
This Clinical Insights describes the process for initiating buprenorphine treatment for patients with opioid use disorder.
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Sexual Dysfunction in Women
The Clinical Problem
Because there is no universal definition of normal sexual function, what constitutes sexual difficulty is determined by a person’s subjective definition of unsatisfactory sexual well-being. The condition is usually described as unsatisfactory interest, arousal, orgasm...
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