Author/s: Wilding, John P.H., Batterham, Rachel L., Calanna, Salvatore, Davies, Melanie, Van Gaal, Luc F., Lingvay, Ildiko, McGowan, Barbara M., Rosenstock, Julio, Tran, Marie T.D., Wadden, Thomas A.,, Sean, Yokote, Koutaro, Zeuthen, Niels, Kushner, Robert F., STEP 1 Study Group
Background: Obesity is a global health challenge with few pharmacologic options. Whether adults with obesity can achieve weight loss with once-weekly semaglutide at a dose of 2.4 mg as an adjunct to lifestyle intervention has not been confirmed.
Methods: ...
Author/s: Tobin, Daniel G., Holt, Stephen R., Doolittle, Benjamin R.
Physicians have a legal and ethical duty to protect their patients and support them during times of clinical need; the decision to end a doctor-patient relationship should not be made lightly. However, in a recent survey of 794 primary care practices, 90% reported discharging patients in the...
Author/s: US Preventive Services Task Force
Importance: Lung cancer is the second most common cancer and the leading cause of cancer death in the US. In 2020, an estimated 228 820 persons were diagnosed with lung cancer, and 135 720 persons died of the disease. The most important risk factor for lung cancer is smoking....
Author/s: Miller, Benjamin F., Coffey, M. J.
KEY POINTS:
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Suicide rates have been rising during the past several years, but suicide is preventable.
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There are many known risk factors for suicide, but the predictive utility of any single risk factor is low, requiring a focus on population-level rather than...
Author/s: Mendelson, Scott J., Prabhakaran, Shyam
Importance: Stroke is the fifth leading cause of death and a leading cause of disability in the United States, affecting nearly 800 000 individuals annually.
Observations: Sudden neurologic dysfunction caused by focal brain ischemia with imaging evidence...
The 46th Annual Advances in Pediatrics is a one-day course for community Pediatricians provides an update of what is currently known about COVID-19 in the pediatric patient population both nationally and locally. The course is taught by 17 national and local experts. Each lecture based, active...
Author/s: Sun, Dongmei, Phua, Chai W.
About 11% of patients in primary care reported bleeding symptoms in a 2010 Canadian study.1 Mild bleeding disorders should be considered in patients with disproportionate bleeding (i.e., excessive postsurgical bleeding...
Author/s: Whittaker, Robyn, McRobbie, Hayden, Bullen, Chris, Rodgers, Anthony, Gu, Yulong, Dobson, Rosie
Background: Mobile phone-based smoking cessation support (mCessation) offers the opportunity to provide behavioural support to those who cannot or do not want face-to-face support. In addition, mCessation can be automated and therefore provided affordably even in resource-poor...
Author/s: Dela Cruz, Adriane M., Walker, Robrina, Pipes, Ronny, Wakhlu, Sidarth, Trivedi, Madhukar H.
Background: The treatment capacity for opioid use disorder (OUD) lags far behind the number of patients in need of treatment. Capacity is limited, in part, by the limited number of physicians who offer office based OUD treatment with buprenorphine. Measurement based care (MBC)...
Chronic pain is common in the U.S., with anywhere from 11% to 40% of the adult population reporting daily pain.1 Approximately one-third of patients experiencing pain receive a pain medication.2 While the number of prescriptions for pain management have declined in recent years3, opioid misuse...