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Why We Should Target Small Airways Disease in Our Management of Chronic Obstructive Pulmonary Disease

Author/s: Usmani, O., Dhand, R., Lavorini, F., Price, D.

For more than 50 years, small airways disease has been considered a key feature of chronic obstructive pulmonary disease (COPD) and a major cause of airway obstruction. Both preventable and treatable, small airways disease has important clinical consequences if left unchecked. Small airways...

Keywords/Tags:
Small Airways Disease chronic obstructive pulmonary disease copd

Milestones in Heart Failure: How Far We Have Come and How Far We Have Left to Go

Author/s: H., Kela, I., Kakarlala, C., Hassan, M., Belavadi, R., Gudigopuram, S. V. R., Raguthu, C., Modi, S., Sange, I.

Heart failure is a clinically complex syndrome that results due to the failure of the ventricles to function as pump and oxygenate end organs. The repercussions of inadequate perfusion are seen in the form of sympathetic overactivation and third spacing, leading to clinical signs of increased...

Keywords/Tags:
heart failure Cardiology Ventricles blood pressure

Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients

Author/s: Bernal, A. J., Gomes da Silva, M., Musungaie, D., Kovalchuk, E., Gonzalez, A., Delos Reyes, V., Martin-Quiros, A., Caraco, Y., Williams-Diaz, A., Brown, M., Du, J., Pedley, A., Assaid, C., Strizki, J., Grobler, J., Shamsuddin, H., Tipping, R., Wan, H., Paschke, A., Butterton, J., Johnson, M., De Anda, C., MOVe-OUT Study Group

Abstract
Background: New treatments are needed to reduce the risk of progression of coronavirus disease 2019 (Covid-19). Molnupiravir is an oral, small-molecule antiviral prodrug that is active against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Methods: We...

Keywords/Tags:
Molnupiravir Oral Treatment COVID-19 Nonhospitalized Patients

COVID-19 and Pregnancy

Author/s: Walter, K.

Pregnant and recently pregnant individuals who become infected with the COVID-19 virus
are at high risk of requiring extra medical care.
According to the Centers for Disease Control and Prevention (CDC),
between January 22, 2020, and November 29, 2021, 148 327
pregnant...

Keywords/Tags:
Pregnancy COVID-19 Center for Disease Control CDC

Screening and Interventions to Prevent Dental Caries in Children Younger Than 5 Years US Preventive Services Task Force Recommendation Statement

Author/s: US Preventative Services task Force

IMPORTANCE Dental caries is the most common chronic disease in children in the US.
According to the 2011-2016 National Health and Nutrition Examination Survey, approximately
23% of children aged 2 to 5 years had dental caries in their primary teeth. Prevalence is higher
in...

Keywords/Tags:
Dental Caries screening Intervention children

Dietary Approaches to Improve Efficacy and Control Side Effects of Levodopa Therapy in Parkinson's Disease: A Systematic Review

Author/s: Boelens Keun, J., Arnoldussen, I., Vriend, C., Van de Rest, O.

Although levodopa remains the most effective drug for symptomatic management of Parkinson's Disease (PD), treatment during advanced disease stages may raise unpredictable motor fluctuations and other complications. Counteracting these complications with other pharmacological therapies may prompt...

Keywords/Tags:
diet Levodopa Therapy Parkinson's Disease PD Side Effects

Myocarditis after BNT162b2 mRNA Vaccine against Covid-19 in Israel

Author/s: Mevorach, D., Anis, E., Cedar, N., Bromberg, M., Haas, E. J., Nadir, E., Olsha-Castell, S., Arad, D., Hasin, T., Levi, N., Asleh, R., Amir, O., Meir, K., Cohen, D., Dichtiar, R., Novick, D., Hershkovitz, Y., Dagan, R., Leitersdorf, I., Ben-Ami, R., Miskin, I., Saliba, W., Muhsen, K., Levi, Y., Green, M. S., Beinan-Boker, L., Alroy-Preis, S.

Background: Approximately 5.1 million Israelis had been fully immunized against coronavirus disease 2019 (Covid-19) after receiving two doses of the BNT162b2 messenger RNA vaccine (Pfizer-BioNTech) by May 31, 2021. After early reports of myocarditis during adverse events monitoring, the Israeli...

Keywords/Tags:
myocarditis Coronovirus COVID-19 Immunization vaccine

Occupational causes of hypersensitivity pneumonitis: a systematic review and compendium

Author/s: Kongsupon , N., Walters, G. I., Sadhra, S. S.

Background: Hypersensitivity pneumonitis (HP) is caused by a variety of antigens and low-molecular-weight chemicals, often through occupational exposure. Making a diagnosis of HP and identifying a cause are challenging. Cryptogenic cases are frequently reported, and missing or incomplete...

Keywords/Tags:
Hypersensitivity Pneumonitis Systemic Review Compendium Occupational Health HP

Postacute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection A State-of-the-Art Review

Author/s: Jiang, D. H., Roy, D. J., Gu, B. J., Hassett, L. C., McCoy, R. G.

The vast majority of patients (>99%) with severe acute respiratory syndrome coronavirus 2 survive immediate infection
but remain at risk for persistent and/or delayed multisystem. This review of published reports through May 31, 2021,
found that manifestations of postacute...

Keywords/Tags:
COVID-19 coronavirus Postacute Secuelae Acute Respiratory Syndrome Infection

Screening for Chlamydia and Gonorrhea: US Preventive Services Task Force Recommendation Statement

Author/s: M. J., Mangione, C. M., Cabana, M., Caughey, A. B., Davis, E. M., Donahue, K. E., Doubeni, C. A., Krist, A. H., Kubik, Li, L., Ogedegbe, G., Pbert, Silverstein, Simon, M. A., Stevermer, J., Tseng, C., Wong, J. B.

Importance: Chlamydia and gonorrhea are among the most common sexually transmitted infections in the US. Infection rates are highest among adolescents and young adults of both sexes. Chlamydial and gonococcal infections in women are usually asymptomatic and may lead to pelvic inflammatory...

Keywords/Tags:
Chlamydia gonorrhea Recommendation Statement Sexually Transmitted Infection Young Adults US

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