Objective. To summarize the effects of long-term osteoporosis drug treatment (ODT) and ODT discontinuation and holidays on fractures and harms.
Data sources. MEDLINE®, Embase®, and Cochrane databases from 1995 to October 2018; ClinicalTrials.gov;...
Recent Resources
Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention: A Systematic Review
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Association of State Laws With Influenza Vaccination of Hospital Personnel
Introduction
Healthcare personnel influenza vaccination can reduce influenza illness and patient mortality. State laws are one tool promoting healthcare personnel influenza vaccination.
Methods
A 2016 legal assessment in 50 states and Washington DC identified (1) assessment...
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Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
BACKGROUND
Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve...
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A Systematic Review of Trials to Improve Child Outcomes Associated With Adverse Childhood Experiences
Context
The purpose of this systematic literature review was to summarize current evidence from RCTs for the efficacy of interventions involving pediatric health care to prevent poor outcomes associated with adverse childhood experiences measured in childhood (C-ACEs).
Evidence...
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Influence of changes in diet quality on unhealthy aging: the Seniors-ENRICA cohort
Background
Whether adopting a better diet in late life influences the aging process is still uncertain. Thus, we examined the association between changes in diet quality and unhealthy aging.
Methods
Data came from 2042 individuals aged ≥ 60 years recruited in the Seniors-...
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Does CBD Actually Work?
Perhaps you’ve heard a lot of people are using CBD.
The chemical compound, naturally occurring in cannabis plants, doesn’t get you high, but does have a wide swath of other purported...
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Treatment of Nonmetastatic Breast Cancer
The treatment of breast cancer has evolved largely based on refinements in understanding of the biology of the disease and the variable risk for mortality among separate disease subtypes.1 Further, due to...
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Tapering Long-term Opioid Therapy in Chronic Noncancer Pain: Evidence and Recommendations for Everyday Practice
Increasing concern about the risks and limited evidence supporting the therapeutic benefit of long-term opioid therapy for chronic noncancer pain are leading prescribers to consider discontinuing the use of opioids. In addition to overt addiction or diversion, the presence of adverse effects,...
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Psyllium fiber improves glycemic control proportional to loss of glycemic control: a meta-analysis of data in euglycemic subjects, patients at risk of type 2 diabetes mellitus, and patients being treated for type 2 diabetes mellitus
BACKGROUND:
A number of health benefits are associated with intake of soluble, viscous, gel-forming fibers, including reduced serum cholesterol and the attenuation of postprandial glucose excursions.
OBJECTIVE:
We assess the effects of psyllium, which is a soluble, gel-...
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Vitamin D and diabetic foot ulcer: a systematic review and meta-analysis
We aimed to evaluate the association between vitamin D deficiency and diabetic foot ulcer (DFU) in patients with diabetes. Pubmed, EMBASE, BIOSIS, the Cochrane Library, and Web of Knowledge, last updated in July 2018, were searched. We assessed eligible studies for the association between...
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