Apolipoprotein (apo) B measurement is a recommended alternative to low-density lipoprotein cholesterol (LDL-C)
The 2021 Canadian Cardiovascular Society guideline on dyslipidemia recommends that physicians may use levels of either non-high-density lipoprotein cholesterol (HDL-C) or apo B...
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Apolipoprotein B in cardiovascular risk assessment
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Catheter ablation and lower risk of incident dementia and mortality in older adults with atrial fibrillation
Background: Atrial fibrillation (AF) has consistently been associated with a higher risk of incident dementia. Observational evidence has suggested catheter ablation may be associated with a lower risk of dementia in patients with AF, but further research is needed. The objectives of this study...
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Perioperative Management of Anticoagulant and Antiplatelet Therapy
The management of patients who are receiving an anticoagulant or antiplatelet drug and require surgery or an invasive procedure is a common clinical problem encountered by a broad spectrum of health care professionals. This review provides an evidence-based but practical approach to common...
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Stress urinary incontinence and synthetic mesh midurethral slings in women
Stress urinary incontinence has a prevalence of 10%–40% and is considered severe in 3%–17% of women worldwide.1 Diagnosis involves demonstrating involuntary urine leakage with increases in intra-abdominal pressure (e.g., exercising, coughing). On history, it is important to differentiate this...
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Oral Nonprescription Pain Medications for Adults
Some prescription pain medications prescribed by doctors also include a nonprescription pain medication. Therefore, to avoid taking more than the recommended amount of acetaminophen or an NSAID, it is important to tell your doctor if you are taking over-the-counter pain medications in addition...
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Pelvic organ prolapse
Prolapse is found in 41%–50% of adult females, with symptoms of pelvic pressure and vaginal bulge sensation reported by 3%–6% of adult females. Prolapse is diagnosed and staged with physical examination based on the maximum descent of vaginal tissue (anterior, posterior or apex) on Valsalva...
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Comparative Efficacy of Pharmacological Treatments for Acne Vulgaris: A Network Meta-Analysis of 221 Randomized Controlled Trials
PURPOSE Acne is an extremely common skin disease with an estimated global prevalence of 9.4%. We aim to provide comprehensive comparisons of the common pharmacological treatments for acne.
METHODS Randomized controlled trials comparing the efficacy of pharmacological therapies for acne...
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Low-Dose Aspirin and the Risk of Stroke and Intracerebral Bleeding in Healthy Older People
Importance Low-dose aspirin has been widely used for primary and secondary prevention of stroke. The balance between potential reduction of ischemic stroke events and increased intracranial bleeding has not been established in older individuals.
Objective To establish the risks of...
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What Parents Should Know About Bugs and Bug Repellents
What Parents Should Know About Bugs and Bug Repellents
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Management of Latent Tuberculosis Infection
In theUS, approximately 13million people have latent tuberculosis infection (LTBI),definedaspeoplewhoareinfectedwithMycobacterium
tuberculosiswho do not have symptoms and do not transmit the disease.Without treatment, approximately 5% to 10% of immunocompetent personswithLTBI develop...
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