Opioids were involved in 42,249 deaths in the United States in 2016, and opioid overdoses have quintupled since 1999.1 Among the causes behind these statistics is increased opiate prescribing by physicians—with primary care providers accounting for about one half of opiate prescriptions.2 As a...
Library & Search Results
Management of Systolic BP in the Elderly
Discuss management of blood pressure in the elderly:
§ Disease or risk factor
§ BP components and their significance
§ Benefits and hazards of BP reduction
§ Other ways to reduce CV risk and law of diminishing returns
§ BP...
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Noninvasive Nonpharmacological Treatment for Chronic Pain: Evidence Summary
Purpose of Review
To assess which noninvasive nonpharmacological treatments for common chronic pain conditions improve function and pain for at least 1 month after treatment.
Key Messages
• Interventions that improved function and/ or pain for at least 1 month when used for...
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Gabapentin for Chronic Neuropathic Pain in Adults
BACKGROUND:
Gabapentin is commonly used to treat neuropathic pain (pain due to nerve damage). This review updates a review published in 2014, and previous reviews published in 2011, 2005 and 2000.
OBJECTIVES:
To assess the analgesic efficacy and adverse effects of gabapentin...
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Amitriptyline for Neuropathic Pain in Adults
BACKGROUND:
This is an updated version of the original Cochrane review published in Issue 12, 2012. That review considered both fibromyalgia and neuropathic pain, but the effects of amitriptyline for fibromyalgia are now dealt with in a separate review.Amitriptyline is a tricyclic...
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Short- and Long-Term Outcomes after Bariatric Surgery in the Medicare Population
Introduction. We conducted a technology assessment to summarize and appraise the current evidence regarding the effectiveness and safety of bariatric surgery in the Medicare-eligible population.
Data Sources. We searched six bibliographic databases and...
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Effects of Aspirin on Risks of Vascular Events and Cancer According to Bodyweight and Dose: Analysis of Individual Patient Data from Randomised Trials
BACKGROUND:
A one-dose-fits-all approach to use of aspirin has yielded only modest benefits in long-term prevention of cardiovascular events, possibly due to underdosing in patients of large body size and excess dosing in patients of small body size, which might also affect other outcomes...
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Alcohol use and burden for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
Background
Alcohol use is a leading risk factor for death and disability, but its overall association with health remains complex given the possible protective effects of moderate alcohol consumption on some conditions. With our comprehensive approach to health accounting within the...
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Featured Review: Vertebroplasty for treating spinal fractures due to osteoporosis
High quality evidence shows that vertebroplasty does not provide more clinically important benefits than placebo but may cause people harm.
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Omega-6 fats for the primary and secondary prevention of cardiovascular disease
BACKGROUND:
Omega-6 fats are polyunsaturated fats vital for many physiological functions, but their effect on cardiovascular disease (CVD) risk is debated.
OBJECTIVES:
To assess effects of increasing omega-6 fats (linoleic acid (LA), gamma-linolenic acid (GLA), dihomo-gamma-...
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