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Effect of an Intranasal Corticosteroid on Quality of Life and Local Microbiome in Young Children With Chronic Rhinosinusitis: A Randomized Clinical Trial

Author/s: Latek, M., Lacwik, P., Molinska, K., Blauz, A., Lach, J., Rychlik, B., Strapagiel, D., Majak, J., Czech, D., Seweryn, M., Kuna, P., Palczynski, C., Majak, P.

Importance: Intranasal corticosteroids (INCs) remain the first-line treatment of chronic rhinosinusitis (CRS) in both adults and children, despite the lack of evidence regarding their efficacy in the pediatric population. Similarly, their effect on the sinonasal microbiome has not been well...

Keywords/Tags:
quality of life Lymphocytes Child, Preschool Sodium Chloride / therapeutic use Chronic Disease

Nocturnal hypoglycemia is underdiagnosed in older people with insulin-treated type 2 diabetes: The HYPOAGE observational study

Author/s: Boureau, A., Guyomarch, B., Gourdy, P., Allix, I., Annweiler, C., Cervantes, N., Chapelet, G., Delabriere, I., Guyonnet, S., Litke, R., Paccalin, M., Penfornis, A., Saulnier, P., Wargny, M., Hadjadj, S., de Decker, L., Cariou, B.

Background: There is a lack of real-life data regarding the frequency and predictive factors of hypoglycemia in older patients with type 2 diabetes (T2D). This study aimed to determine the frequency and predictors of hypoglycemia in older patients with insulin-treated T2D.

Methods: This...

Keywords/Tags:
basal insulin analogues continuous glucose monitoring glycemic control Hypoglycemics type 2 diabetes

Patient-Reported Outcomes 12 Years after Localized Prostate Cancer Treatment

Author/s: Donovan, J. L., Hamdy, F. C., Lane, J. A., Young, G. J., Metcalfe, C., Walsh, E. I., Davis, M., Steuart-Feilding, T., Blazeby, J. M., Avery, K. N., Martin, R. M., Bollina, P., Doble, A., Doherty, A., Gillatt, D., Gnanapragasam, V., Hughes, O., Kockelbergh, R., Kynaston, H., Paul, A., Paez, E., Powell, P., Rosariom D. J., Rowe, E., Manson, M., Catto, J. W., Peters, T. J., Wade, J., Turner, E. L., Williams, N. J., Oxley, J., Staffurth, J., Bryant, R. J., Neal, D. E.

Long-term patient-reported outcomes are needed to inform treatment decisions for localized prostate cancer.

METHODS
Patient-reported outcomes of 1643 randomly assigned participants in the ProtecT (Prostate Testing for Cancer and Treatment) trial were evaluated to assess the...

Keywords/Tags:
Androgens Prostatectomy Patient Reported Outcome Measures prostate cancer surgery

Fifteen-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer

Author/s: Hamdy, Freddie, Donovan, Jenny, Lane, Athene, Metcalfe, Chris, Davis, Michael, Turner, Emma, Martin, Richard, Young, Grace, Walsh, Eleanor, Bryant, Bollina, Prasad, Doble, Andrew

Background

Between 1999 and 2009 in the United Kingdom, 82,429 men between 50 and 69 years of age received a prostate-specific antigen (PSA) test. Localized prostate cancer was diagnosed in 2664 men. Of these men, 1643 were enrolled in a trial to evaluate the effectiveness of treatments,...

Keywords/Tags:
prostate prostatic Follow-Up Studies male Young Adults

Dynamics of Naturally-Acquired Immunity Against SARS-CoV-2 in Children and Adolescents

Author/s: Patalon, T., Saciuk, Y., Perez, G., Peretz, A., Ben-Tov, A., Gazit, S.

Background
To evaluate the duration of protection against reinfection conferred by a previous SARS-CoV-2 infection in children and adolescents.
Methods
We applied two complementary approaches: a matched test-negative, case-control design and a retrospective cohort design. 458,...

Keywords/Tags:
COVID-19 SARS-CoV-2 waning immunity naturally aquired immunity infection-induced immunity adolescents

Air Quality Index and Childhood Asthma: A Pilot Randomized Clinical Trial Intervention

Author/s: Rosser, F. J., Rothenberger, S. D., Han, Y., Forno, E., Celedón, J. C.

Introduction: To reduce air pollution exposure, the U.S. asthma guidelines recommend that children check the Air Quality Index before outdoor activity. Whether adding the Air Quality Index and recommendations to asthma action plans reduces exacerbations and improves control and quality of life...

Keywords/Tags:
children quality of life asthma air pollution United States

Food Intake Compared to Exercise Association with Obesity in Children Ages 3–6

Author/s: Bedell, D., Sevcik, T., Daly, J. M., Levy, B. T.

Background: Childhood obesity affects 19.3% of children ages 2 to 19 years in the US, and 25.6% of Hispanic children. Study objectives were to (1) assess the feasibility of monitoring physical activity and daily caloric intake in children ages 3 to 6 years, (2) assess whether known obesity risk...

Keywords/Tags:
child overweight eating exercise BMI

Chlorthalidone vs. Hydrochlorothiazide for Hypertension–Cardiovascular Events

Author/s: Ishani, A., Cushman, W. C., Leatherman, S. M., R. A., Woods, P., Glassman, P. A., Taylor, A. A., Hau, C., Klint, A., Huang, G. D., Brophy, M. T., Fiore, L. D., Ferguson, R. E., Diuretic Comparison Project Writing Group

Background: Whether chlorthalidone is superior to hydrochlorothiazide for preventing major adverse cardiovascular events in patients with hypertension is unclear.

Methods: In a pragmatic trial, we randomly assigned adults 65 years of age or older who were patients in the Department of...

Keywords/Tags:
hypertension cardiovascular events heart failure veterans infarction

Cost-effectiveness of management strategies in recurrent acute otitis media

Author/s: Noorbakhsh, K. A., Liu, H., Kurs-Lasky, M., Smith, K. J., Hoberman, A., Shakh, N.

Objective: To evaluate the cost-effectiveness of tympanostomy tube placement vs. nonsurgical medical management, with the option of tympanostomy tube placement in the event of treatment failure, in children with recurrent acute otitis media (AOM).

Study design: A Markov decision model...

Keywords/Tags:
Recurrent acute otitis media ear infections Tympanostomy tube placement nonsurgical medical management acute otitis media

Amoxicillin Versus Other Antibiotic Agents for the Treatment of Acute Otitis Media in Children

Author/s: Frost, H. M., Bizune, D., Gerber, J. S., Hersh, A. L., Hicks, L. A., Tsay, S. V.

Objectives: The objective of the study was to compare the antibiotic treatment failure and recurrence rates between antibiotic agents (amoxicillin, amoxicillin-clavulanate, cefdinir, and azithromycin) for children with uncomplicated acute otitis media (AOM).

Study design: We completed a...

Keywords/Tags:
Amoxicillin-Potassium Clavulanate Combination amoxicillin cefdinir Azithromycin acute otitis media

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