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Severe Pulmonary Disease Associated with Electronic-Cigarette–Product Use — Interim Guidance

Author/s: Schier, JG, Meiman, JG, Layden, J, Mikosz, CA, VanFrank, B, King, BA, Salvatore, PP, Weissman, DN, Thomas, J, Melstrom, PC, Baldwin, GT, Parker, EM, Courtney-Long, EA, Krishnasamy, VP, Pickens, CM, Evans, ME, Tsay, SV, Powell, KM, Kiernan, EA, Marynak, KL, Adjemian, J, Holton, K, Armour, BS, England, LJ, Briss, PA, Houry, D, Hacker, KA, Reagan-Steiner, S, Zaki, S, Meaney-Delman, D, CDC 2019 Lung Injury Response Group

On September 6, 2019, this report was posted as an MMWR Early Release on the MMWR website (https://www.cdc.gov/mmwr). As of August 27, 2019, 215 possible cases of severe pulmonary disease associated with the use of electronic cigarette (e-cigarette)...

Keywords/Tags:
e-cigarettes pulmonary disease nicotine cannabis vaping

Benralizumab for the Prevention of COPD Exacerbations

Author/s: Criner GJ, Celli, BR, Brightling CE, Agusti, A, Papi, A, Singh, D, Sin, DD, Vogelmeier, CD, Sciurba, FC, Bafadhel, M, Backer, V, Kato, M, Ramirez-Venegas, A, Wei, YF, Bjermer, L, Shih, VH, Jison, M, O'Quinn, S, Makulova, N, Newbold, P, Goldman, M, Martin, UJ

BACKGROUND:

The efficacy and safety of benralizumab, an interleukin-5 receptor alpha-directed cytolytic monoclonal antibody, for the prevention of exacerbations in patients with moderate to very severe chronic obstructive pulmonary disease (COPD) are not known.

METHODS:

In...

Keywords/Tags:
benralizumab chronic obstructive pulmonary disease copd

Evidence Update for Clinicians: Treatment Options for People with Posttraumatic Stress Disorder (PTSD)

A recent update of a systematic review, supported by PCORI through a research partnership with AHRQ, informs clinicians on psychological and pharmacological treatments for PTSD in adults. The review reports on 207 articles from 193 studies published before 2018, updating a 2013 review.

...

Keywords/Tags:
post-traumatic stress disorder PTSD CBT cognitive behavior therapy

Meta-Analysis of Oral Anticoagulant Monotherapy as an Antithrombotic Strategy in Patients With Stable Coronary Artery Disease and Nonvalvular Atrial Fibrillation

Author/s: Lee, SR, Rhee, TM, Kang, DY, Choi, EK, Oh, S, Lip, GYH

Guidelines recommend oral anticoagulant (OAC) monotherapy without antiplatelet therapy (APT) in patients with nonvalvular atrial fibrillation (AF) with stable coronary artery disease (CAD) of >1 year after myocardial infarction or percutaneous coronary intervention. More evidences are...

Keywords/Tags:
atrial fibrillation coronary artery disease CAD myocardial infarction stroke

Clinicians’ Guide to Cannabidiol and Hemp Oils

Author/s: VanDolah H.J., Bauer, B.A., Mauck, K.F.

Cannabidiol (CBD) oils are low tetrahydrocannabinol products derived from Cannabis sativa that have become very popular over the past few years. Patients report relief for a variety of conditions, particularly pain, without the intoxicating adverse effects of medical marijuana. In June 2018, the...

Keywords/Tags:
cannabidoil cannabis

Pulmonary Illness Related to E-Cigarette Use in Illinois and Wisconsin - Preliminary Report

Author/s: Layden, J.E., Ghinai, I, Pray, I, Kimball, A, Layer, M, Tenforde, M, Navon, L, Hoots, B, Salvatore, PP, Elderbrook, M, Haupt, T, Kanne, J, Patel, MT, Saathoff-Huber, L, King, BA, Schier, JG, Mikosz, CA, Meiman, J

BACKGROUND:

E-cigarettes are battery-operated devices that heat a liquid and deliver an aerosolized product to the user. Pulmonary illnesses related to e-cigarette use have been reported, but no large series has been described. In July 2019, the Wisconsin Department of Health Services and...

Keywords/Tags:
vaping caution

Final Update Summary: Breast Cancer: Medication Use to Reduce Risk

Author/s: US Preventive Services Task Force, Owens, Douglas K., Davidson, Karina W., Krist, Alex H., Barry, Michael J., Cabana, M, Caughey, AB, Doubeni, Chyke A., Epling, John W. Jr., Kubik, M, Landefeld, CS, Mangione, Carol M., Pbert, L, Silverstein, Michael, Tseng, Chien-Wen, Wong, JB

IMPORTANCE:

Breast cancer is the most common nonskin cancer among women in the United States and the second leading cause of cancer death. The median age at diagnosis is 62 years, and an estimated 1 in 8 women will develop breast cancer at some point in their lifetime. African American...

Keywords/Tags:
breast cancer risk assessment risk reduction medication

Association of Metabolic Surgery With Major Adverse Cardiovascular Outcomes in Patients With Type 2 Diabetes and Obesity

Author/s: Aminian, A, Zajicheck, A, Arterburn, DE, Wolski, KE, Brethauer, SA, Schauer, PR, Kattan, MW, Nissen, SE

IMPORTANCE:

Although metabolic surgery (defined as procedures that influence metabolism by inducing weight loss and altering gastrointestinal physiology) significantly improves cardiometabolic risk factors, the effect on cardiovascular outcomes has been less well characterized.

...

Keywords/Tags:
diabetes, type 2 weight loss obesity bariatric surgery metabolic surgery

Type and timing of menopausal hormone therapy and breast cancer risk: individual participant meta-analysis of the worldwide epidemiological evidence

Author/s: Collaborative Group on Hormonal Factors in Breast Cancer

Summary

Background

Published findings on breast cancer risk associated with different types of menopausal hormone therapy (MHT) are inconsistent, with limited information on long-term effects. We bring together the epidemiological evidence, published and unpublished, on these...

Keywords/Tags:
breast cancer postmenopause menopause estrogen hormone therapy

Assessment and Management of Patients at Risk for Suicide: Synopsis of the 2019 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guidelines.

Author/s: Sall, J., Brenner, J., Bell, A.M.M., Colston, M.J.

These guidelines produced by the VA apply equally well to all adults.  James W. Mold, MD, MPH
Keywords/Tags:
suicide veterans guidelines risk management

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