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Overcoming Barriers to the Diagnosis and Treatment of Insomnia

Author/s: Roth, Thomas

Apply evidence-based diagnostic guidelines for patients who have clinical features consistent with insomnia. Use evidence-based guidelines to develop comprehensive treatment plans that include cognitive-behavioral therapy, pharmacologic treatment, and combination therapies to achieve optimal...

Keywords/Tags:
Insomnia cognitive behavioral therapy Insomnia medications

Maintaining Safety with SARS-CoV-2 Vaccines

Author/s: Castells, Mariana C., Phillips, Elizabeth J.

To date, the development of mRNA vaccines for the prevention of infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a success story, with no serious concerns identified in the ongoing phase 3 clinical trials....

Keywords/Tags:
SARS-CoV-2 SARS coronavirus COVID-19 COVID-19 vaccine vaccines mRNA vaccines Pfizer–BioNTech mRNA vaccine Pfizer

Polypharmacy Management in Older Patients

Author/s: Hoel, Robert W., Giddings-Connolly, Ryan M., Takahashi, Paul Y.

Medications to treat disease and extend life in our patients often amass in quantities, resulting in what has been termed "polypharmacy." This imprecise label usually describes the accumulation of 5, and often more, medications. Polypharmacy in advancing age frequently results in drug therapy...

Keywords/Tags:
RISEOK opioids elderly polypharmacy elderly patients older adults Elderly care

Association of Therapies With Reduced Pain and Improved Quality of Life in Patients With Fibromyalgia: A Systematic Review and Meta-analysis

Author/s: Mascarenhas, Rodrigo O., Souza, Mateus B., Oliveira, Murilo X., Lacerda, Ana C., Mendonca, Vanessa A., Henschke, Nicholas, Oliveira, Vinicius C.

Importance: Fibromyalgia is a chronic condition that results in a significant burden to individuals and society.

Objective: To investigate the effectiveness of therapies for reducing pain and improving quality of life (QOL) in people with fibromyalgia....

Keywords/Tags:
Fibromyalgia quality of life cognitive behavioral therapy pain management

REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19

Author/s: Weinreich, David M., Sivapalasingam, Sumathi, Norton, THomas,, Ali, Shazia, Gao, Haitao, Bhore, Rafia, Musser, Bret J., Soo, Yuhwen, Rofail, Diana, Im, Joseph, Perry, Christina, Pan, Cynthia, Hosain, Romana, Mahmood, Adnan, Davis, John D., Turner, Kenneth C., Hooper, Andrea T., Hamilton, Jennifer D., Baum, Alina, Kyratsous, Christos A., Kim, Yunji, Cook, Amanda, Kampman, Wendy, Kohli, Anita, Sachdeva. Yessica, Graber, Ximena, Kowal, Bari, DiCioccio, Thomas, Stahl, Neil, Lipsich, Leah, Braunstein, Ned, Herman, Gary, Yancopoulos, George D.

Background: Recent data suggest that complications and death from coronavirus disease 2019 (Covid-19) may be related to high viral loads.

Methods: In this ongoing, double-blind, phase 1-3 trial involving nonhospitalized patients with Covid-19, we...

Keywords/Tags:
COVID-19 COVID-19 vaccine SARS coronavirus SARS-CoV-2 Antibodies coronavirus

Stepped Exercise Program for Patients With Knee Osteoarthritis: A Randomized Controlled Trial

Author/s: Allen, Kelli D., Bongiorni, Dennis, Caves, Kevin, Coffman, Cynthia J., Floegel, Theresa A., Greysen, Heather M., Hall, Katherine S., Heiderscheit, Bryan, Hoenig, Helen M., Huffman, Kim M., Morey, Miriam D., Ramasunder, Shalini, Severson, Herbert, Smith, Battista, Van Houtven, Courtney, Woolson, Sandra

Background: Physical therapy (PT) and other exercise-based interventions are core components of care for knee osteoarthritis (OA), but both are underutilized, and some patients have limited access to PT services. This clinical trial is examining a STepped Exercise Program for...

Keywords/Tags:
osteoarthritis Knee osteoarthritis Knee Joint veterans exercise therapy

Masks and Face Coverings for the Lay Public : A Narrative Update

Author/s: Czypionka, Thomas, Greenhalgh, Trisha, Bassler, Dirk, Bryant, Manuel B.

Whether and when to mandate the wearing of facemasks in the community to prevent the spread of coronavirus disease 2019 remains controversial. Published literature across disciplines about the role of masks in mitigating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission...

Keywords/Tags:
face masks Face Coverings masks COVID-19 coronavirus SARS coronavirus SARS-CoV-2 Freedom Policy

Weekly and Monthly Subcutaneous Buprenorphine Depot Formulations vs Daily Sublingual Buprenorphine With Naloxone for Treatment of Opioid Use Disorder: A Randomized Clinical Trial

Author/s: Lofwall, Michelle R., Walsh, Sharon L., Nunes, Edward V., Bailey, Genie L., Sigmon, Stacey C., Kampman, Kyle M., Frost, Michael, Tiberg, Fredrik, Linden, Marareta, Sheldon, Behshad, Oosman, Sonia, Peterson, Stefan, Chen, Michael, Kim, Sonnie

Importance: Buprenorphine treatment for opioid use disorder may be improved by sustained-release formulations.

Objective: To determine whether treatment involving novel weekly and monthly subcutaneous (SC) buprenorphine depot formulations is noninferior...

Keywords/Tags:
opioids Opioid Use Disorder Buprenorphine Buprenorphine-naloxone

Mind-Body Therapies for Opioid-Treated Pain: A Systematic Review and Meta-analysis

Author/s: Garland, Eric L., Brintz, Carrie E., Hanley, Adam W., Roseen, Eric J., Atchley, Rachel M., Gaylord, Susan A., Faurot, Keturah R., Yaffe, Joanne, Fiander, Michelle, Keefe, Francis J.

Importance: Mind-body therapies (MBTs) are emerging as potential tools for addressing the opioid crisis. Knowing whether mind-body therapies may benefit patients treated with opioids for acute, procedural, and chronic pain conditions may be useful for prescribers, payers, policy...

Keywords/Tags:
Mind-Body Therapies meditation hypnosis cognitive behavioral therapy pain reduction opioids Opioid Epidemic

Dynamics and Correlation Among Viral Positivity, Seroconversion, and Disease Severity in COVID-19

Author/s: Fu, Yu, Li, Yongsheng, Guo, Ensong, He, Liang, Liu, Jia, Yang, Bin, Li, Fuxia, Wang, Zizhuo, Li, Yuan, Xiao, Rourou, Liu, Chen, Huang, Yuhan, Wu, Xue, Lu, Funian, You, Lixin, Qin, Tianyu, Wang, Chaolong, Li, Kezhen, Wu, Peng, Ma, Ding, Sun, Chaoyang, Chen, Gang

Background: The understanding of viral positivity and seroconversion during the course of coronavirus disease 2019 (COVID-19) is limited.

Objective: To describe patterns of viral polymerase chain reaction (PCR) positivity and evaluate their correlations...

Keywords/Tags:
COVID-19 coronavirus SARS coronavirus Polymerase chain reaction PCR

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