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Covid-19 Vaccines — Immunity, Variants, Boosters

Author/s: Barouch, D. H.

The coronavirus disease 2019 (Covid-19) pandemic has claimed an estimated 15 million lives, including more than 1 million lives in the United States alone. The rapid development of multiple Covid-19 vaccines has been a triumph of biomedical research, and billions of vaccine doses have been...

Keywords/Tags:
United States Biomedical Research vaccines Pandemics Immunity

International normalized ratio and activated partial thromboplastin time testing

Author/s: Chornenki, N. L. J., Fralick, M., Sholzberg, M.

International normalized ratio (INR) and activated partial thromboplastin time (aPTT) have limited clinical utility
The INR and aPTT should be used only for specific clinical indications (see Appendix 1, available at...

Keywords/Tags:
Bleeding disorder direct oral anticoagulants activated partial thromboplastin International normalized ratio Specimen handling

Effects of salt substitutes on clinical outcomes: a systematic review and meta-analysis

Author/s: Yin, X., Rodgers, A., Perkovic, A., Huang, L., Li, K., Yu, J., Wu, Y., Wu, J. H. Y., Marklund, M., Huffman, M. D., Miranda, J. J., Di Tanna, G. L., Labarthe, D., Elliott, P., Tian, M., Neal, B.

Objectives The Salt Substitute and Stroke Study (SSaSS) recently reported blood pressure-mediated benefits of a potassium-enriched salt substitute on cardiovascular outcomes and death. This study assessed the effects of salt substitutes on a breadth of outcomes to quantify the consistency of the...

Keywords/Tags:
hypertension meta-analysis stroke Salt Substitutes blood pressure

Treatment of Clostridioides difficile Infection

Author/s: Sehgal, K., Cifu, A. S., Khanna, S.

GUIDELINE TITLE ACG Clinical Guidelines: Prevention,
Diagnosis, and Treatment of Clostridioides difficile Infections
RELEASE DATE May 18, 2021
PRIOR VERSION 2013
DEVELOPER American College of Gastroenterology (ACG)
FUNDING SOURCE ACG
TARGET POPULATION Adults...

Effect of Stenting Plus Medical Therapy vs Medical Therapy Alone on Risk of Stroke and Death in Patients With Symptomatic Intracranial Stenosis The CASSISS Randomized Clinical Trial

Author/s: Gao, P., Wang, T., Wang, D., Liebeskind, D. S.", H., Li, T., Zhao, Z., Cai, Y., Wu, W., He, W., Yu, J., Zheng, B., Wang, H., Wu, Y., Dmytriw, A. A., Krings, T., Derdeyn, C. P., Jiao, L., CASSISS Trial Investigators

Importance: Prior randomized trials have generally shown harm or no benefit of stenting added to medical therapy for patients with symptomatic severe intracranial atherosclerotic stenosis, but it remains uncertain as to whether refined patient selection and more experienced surgeons might result...

Keywords/Tags:
randomized controlled trial Multicenter Study Treatment Outcome Pathologic Constriction stroke Stent

Fixed drug eruption

Author/s: Chou, Yu-Ju, Chang, Hua-Ching

A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot.
Keywords/Tags:
drug eruptions asymptomatic erythematous doxycycline

Occupational hypersensitivity pneumonitis after polyurethane adhesive exposure

Author/s: Arbaaz, Hasany, Aasim, Tarlo, Susan M.

Key points
• Hypersensitivity pneumonitis is a type of interstitial lung
disease that requires early diagnosis and treatment as it may
lead to progressive pulmonary fibrosis.
• An occupational history is essential when evaluating patients
with respiratory symptoms....

Keywords/Tags:
adhesives Polyurethanes pneumonitis Hypersensitivity Pneumonitis

Therapy for Mild to Moderate Asthma

Author/s: Gray, S. E., Cife, A. S., Press, V. G.

GUIDELINE TITLE Global Strategy for Asthma Management
and Prevention (GINA Strategy Report)
RELEASE DATE April 26, 2021
PRIOR VERSION April 3, 2020
DEVELOPER AND FUNDING SOURCE The Global Initiative for
Asthma (GINA)
TARGET POPULATION Patients aged 12 y with...

Keywords/Tags:
asthma Mild to Moderate Asthma therapy recommendations Asthma Therapy

Effect of Physical Therapy vs Arthroscopic Partial Meniscectomy in People With Degenerative Meniscal Tears: Five-Year Follow-up of the ESCAPE Randomized Clinical Trial

Author/s: Noorduyn, J. C. A., Van de Graaf, V. A., Willigenburg, N. W., Scholten-Peeters, G. G. M., Kret, Kret, E. J., Van Dijk, R. A., Buchbinder, R., Hawker, G. A., Coppieters, M. W., Poolman, R. W., ESCAPE Research Group

Importance: There is a paucity of high-quality evidence about the long-term effects (ie, 3-5 years and beyond) of arthroscopic partial meniscectomy vs exercise-based physical therapy for patients with degenerative meniscal tears.

Objectives: To compare the 5-year effectiveness of...

Keywords/Tags:
Knee Injuries Follow-Up Studies randomized controlled trial Meniscus Injuries Meniscectomy

The Effectiveness of Intraosseous Basivertebral Nerve Radiofrequency Ablation for the Treatment of Vertebrogenic Low Back Pain: An Updated Systematic Review with Single-Arm Meta-analysis

Author/s: Conger, A., Burnham, T. R., Clark, T., Teramoto, M, McCormick, Z. L.

Objective. To provide an estimate of the effectiveness of basivertebral nerve (BVN) radiofrequency ablation (RFA) to
treat vertebrogenic low back pain (LBP). Design. Systematic review with single-arm meta-analysis. Population.
Persons 18 years of age with chronic LBP associated with...

Keywords/Tags:
Endplate Vertebrogenic Discogenic Modic Ablation

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