Objective: To assess the benefits and harms of lipid-lowering therapies used to prevent or manage cardiovascular disease including bile acid sequestrants (BAS), ezetimibe, fibrates, niacin, omega-3 supplements, proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors, and statins.
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Lipid-lowering therapies for cardiovascular disease prevention and management in primary care
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Clinical practice guideline for management of osteoporosis and fracture prevention in Canada: 2023 update
Fracture risk increases with advancing age, as a result of declining skeletal strength and increased risk of falling. In Canada, more than 2 million people live with osteoporosis.1 Every year in Canada, about 150 people per 100 000 suffer a hip fracture, which is considered among the most...
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Ankyloglossia (tongue tie) in infants
The lingual frenulum is a tissue fold created by tongue elevation. In ankyloglossia, oral examination may reveal a short, tight frenulum that inserts either toward the tongue tip or onto the mandibular alveolus (the tooth-bearing surface of the lower jaw). Clinicians should evaluate range of...
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Nurse Standing Orders for Buprenorphine Follow-Up Care in a Community Health Center Network
Background: Less than 20% of individuals with opioid use disorder (OUD) are receiving a medication treatment for OUD in the United States. Though nurses can assume critical roles in outpatient models of OUD care, there are no published reports of buprenorphine standing orders for nurses that...
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Buprenorphine Dose and Time to Discontinuation Among Patients With Opioid Use Disorder in the Era of Fentanyl
Question: Are higher doses of buprenorphine treatment for opioid use disorder associated with improved retention in treatment when use of fentanyl (vs heroin) is more prevalent?
Findings: In this cohort study of 6499 patients initiating buprenorphine treatment between 2016 and 2020,...
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Multimodal non-invasive non-pharmacological therapies for chronic pain: mechanisms and progress
Chronic pain conditions impose significant burdens worldwide. Pharmacological treatments like opioids have limitations. Non-invasive non-pharmacological therapies (NINPT) encompass diverse interventions including physical, psychological, complementary and alternative approaches, and other...
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American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline
The purpose of the American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline is to provide recommendations to assist primary care and other clinicians in the care of female adult survivors of breast cancer. A systematic review of the literature was...
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Breast Cancer Survivorship Guidelines
What Is the American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline?
The Breast Cancer Survivorship Care Guideline is advice from the American Cancer Society and the American Society of Clinical Oncology to help doctors, nurses, and other...
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Tick-borne red meat allergy (α-gal syndrome)
Tick-borne red meat allergy occurs from sensitization to a carbohydrate, galactose-α-1,3-galactose (α-gal)
The lone star tick (Amblyomma americanum) is commonly found in the southern United States, but its prevalence in Canada is increasing.1 The tick’s saliva contains a high level of α-...
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Nirmatrelvir or Molnupiravir Use and Severe Outcomes From Omicron Infections
Question: What outcomes are associated with ritonavir-boosted nirmatrelvir or molnupiravir use for outpatient treatment of SARS-CoV-2 Omicron subvariants, particularly BQ.1.1 and XBB.1.5, in high-risk individuals?
Findings: In a cohort study of 68 867 patients who received a diagnosis...
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