Studies have shown bidirectional relationships between short- or long-sleep duration and risk for obesity, non-communicable diseases, all-cause mortality and cardiovascular disease mortality. Increasing sleep duration may be an appropriate strategy to reduce cardiometabolic riskin short-sleeping...
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Periprocedural Bridging in Patients with Venous Thromboembolism: A Systematic Review
Abstract
BACKGROUND:
Vitamin K antagonists (VKA) are the most widely used anticoagulants, and bridging is commonly administered during periprocedural VKA interruption. Given the unclear benefits and risks of periprocedural bridging in patients with previous venousthromboembolism,...
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Spending at least 120 minutes a week in nature is associated with good health and wellbeing
Spending time in natural environments can benefit health and well-being, but exposure-response relationships are under-researched. We examined associations between recreational nature contact in the last seven days and self-reported health and well-being. Participants (n = 19,806) were drawn...
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Consistency of Direct to Consumer Genetic Testing Results Among Identical Twins
Abstract
Purpose
To evaluate the consistency of 3 commonly used direct to consumer genetic testing kits.
Background
Genetic testing kits are widely marketed by several companies but the consistency of their results is unclear. Since identical twins share the same DNA...
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Primary Prevention of Sudden Cardiac Death
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In patients with heart failure with reduced ejection fraction (<40%), guideline-directed medical therapy (GDMT) is recommended to reduce sudden cardiac death and all-cause mortality; GDMT includes β-blockers; mineralocorticoid receptor antagonists; and angiotensin-converting enzyme...
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Preexposure Prophylaxis for the Prevention of HIV Infection: US Preventive Services Task Force Recommendation Statement
Abstract
IMPORTANCE:
An estimated 1.1 million individuals in the United States are currently living with HIV, and more than 700 000 persons have died of AIDS since the first cases were reported in 1981. In 2017, there were 38 281 new diagnoses of HIV infection reported in the...
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Cardiovascular Events and Mortality in White Coat Hypertension: A Systematic Review and Meta-analysis
BACKGROUND:
The long-term cardiovascular risk of isolated elevated office blood pressure (BP) is unclear.
PURPOSE:
To summarize the risk for cardiovascular events and all-cause mortality associated with untreated white coat hypertension (WCH) and treated white coat effect (...
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Intensive Glucose Control in Patients with Type 2 Diabetes — 15-Year Follow-up
BACKGROUND
We previously reported that a median of 5.6 years of intensive as compared with standard glucose lowering in 1791 military veterans with type 2 diabetes resulted in a risk of major cardiovascular events that was significantly lower (by 17%) after a total of 10 years of combined...
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Interventions for hand eczema
Abstract
BACKGROUND:
Hand eczema is an inflammation of the skin of the hands that tends to run a chronic, relapsing course. This common condition is often associated with itch, social stigma, and impairment in employment. Many different interventions of unknown effectiveness are...
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Preventing Firearm-Related Death and Injury
Deaths and injuries from firearms are significant public health problems, and clinicians are in a unique position to identify risk among their patients and discuss the importance of safe firearm practices. Although clinicians may be ill-prepared to engage in such discussions, an adequate body of...
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